The Robert Packard Center for ALS Research at Johns Hopkins is celebrating its 25th anniversary, highlighting its legacy as a global leader in ALS research and innovation. Over the years, the Center has funded groundbreaking studies, including 50% of clinical trials in the past decade and two FDA-approved drugs, while fostering global collaboration. Its high-risk, high-reward funding model supports cutting-edge research often overlooked by traditional funders. The Center mandates collaboration through regular meetings and an annual symposium, accelerating the pace and quality of ALS research. With 70% of grants awarded outside Johns Hopkins and 13% internationally, it champions open science and a global research ecosystem. Looking ahead, the Center aims to continue advancing therapies and ultimately find a cure for ALS through ongoing collaboration and support.